Melanoma-Derived Small Extracellular Vesicles Induce Lymphangiogenesis and Metastasis through an NGFR-Dependent Mechanism

Scientists found that small extracellular vesicles derived from metastatic melanoma cell lines were enriched in nerve growth factor receptor, spread through the lymphatic system and were taken up by lymphatic endothelial cells, reinforcing lymph node metastasis.