epilepsy

[Nature Reviews Neurology] The authors review evidence that amyloid-β (Aβ) forms part of a shared pathway between epilepsy and cognitive decline, particularly in the context of Alzheimer's disease.

[Archives of Pharmacal Research] We herein review a potential role of the major cellular components of the blood-brain barrier (BBB), with a focus on the contribution of BBB disruption, in neurodegenerative disease progression.

[Nature Communications] Scientists generated human induced pluripotent stem cell (hiPSC) lines from a patient with Tuberous Sclerosis Complex (TSC) and genetically engineer counterparts and isogenic controls. By differentiating hiPSCs, we show that control neurons respond to canonical guidance cues as predicted.

[Molecular Psychiatry] Induced pluripotent stem cells derived from individuals deficient in CDKL5 protein were used to generate neural cells. Proteomic and phosphoproteomic approaches revealed disruption of several pathways, including microtubule-based processes and cytoskeleton organization.

[Physiological Reviews] Scientists review the well-characterized genetics and pathophysiology of the periodic paralyses of skeletal muscle, and then use this information as a foundation for advancing our understanding of mutations in the structurally homologous a subunits of brain sodium channels that cause epilepsy, migraine, autism, and related co-morbidities.

[Cell Death & Disease] Scientists found that loss of Fgf9 in olig1 progenitor cells induced epilepsy in mice, with pathological changes in the cortex. Then depleting Fgf9 in different neural populations revealed that epilepsy was associated with GABAergic neurons.