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Pulmonary Cell NewsScientists generated human induced pluripotent stem cell (hiPSC) lines from a patient with Tuberous Sclerosis Complex (TSC) and genetically engineer counterparts and isogenic controls. By differentiating hiPSCs, we show that control neurons respond to canonical guidance cues as predicted.
[Nature Communications]
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Catlett, T. S., Onesto, M. M., McCann, A. J., Rempel, S. K., Glass, J., Franz, D. N., & Gómez, T. M. (2021). RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex. Nature Communications, 12(1), 2589. https://doi.org/10.1038/s41467-021-22770-4 Cite
