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epithelial cells

Epithelial Plasticity in COPD Results in Cellular Unjamming Due to an Increase in Polymerized Actin

[Journal of Cell Science] Both cigarette smoke-exposed and COPD-patient derived epithelia displayed quantitative evidence of cellular plasticity, with loss of specialized apical features and a transcriptional profile suggestive of partial epithelial to mesenchymal transition, albeit with distinct cell motion indicative of cellular unjamming.

Tumor Cell Apoptosis Modulates the Colorectal Cancer Immune Microenvironment via Interleukin-8-Dependent Neutrophil Recruitment

[Cell Death & Disease] The authors investigated the impact of apoptotic colorectal cancer cells on neutrophils and its consequence on other immune cells of the tumor microenvironment.

The Ubiquitin E3 Ligase ARIH1 Regulates hnRNP E1 Protein Stability, EMT and Breast Cancer Progression

[Oncogene] Investigators demonstrated that hnRNP-E1 protein stability was increased upon ARIH1 silencing, whereas, overexpression of ARIH1 leads to a reduction in hnRNP-E1.

Estradiol Reduces ACE2 and TMPRSS2 mRNA Levels in A549 Human Lung Epithelial Cells

[Drug Development Research] Researchers examined the effects of in vitro treatment of A549 human lung epithelial cells with 17-Ī²-estradiol on mRNA expression of genes coding for these proteins.

High-Definition DIC Imaging Uncovers Transient Stages of Pathogen Infection Cycles on the Surface of Human Adult Stem Cell-Derived Intestinal Epithelium

[mBio] Investigators developed a method for live-cell imaging of microbial infection dynamics on human adult stem cell-derived intestinal epithelial cell layers.

A Comparative Study on the Model of PM2.5 Direct or Indirect Interaction with Bronchial Epithelial Cells

[Environmental Science and Pollution Research] The authors examined the viability of BEAS-2B and mRNA/protein expression profile of oxidative stress and inflammatory response-related transcription factors Nrf2, NF-kB, and according inflammatory indicators such as IL-1, IL-6, and IL-8, with a view to evaluating the effects of different interaction models of PM2.5 on epithelial cell damage in vitro.

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