epithelial cells

[Journal of Reproduction and Development] Bovine trophoblast cells were obtained from bovine placenta and immortalized by transfection with telomerase reverse transcriptase. Scientists demonstrated that trophoblast-derived exosome proteins were one of the most critical elements in fetomaternal interaction, and their changes might act as a key signal in altering endometrial receptivity and provided a potential target for improving fertility.

[Mucosal Immunology] A combination of genetic and genomic approaches were used to define a critical role of IEC-intrinsic negative elongation factor (NELF) complex in maintenance of epithelial homeostasis.

[Journal of Allergy and Clinical Immunology] Scientists generated human thymic epithelial progenitors from human embryonic stem cells and to assess their thymopoietic function in vivo.

[Science Immunology] Investigators employed a multi-omics analysis combined with artificial intelligence in a young patient cohort where major comorbidities were excluded at the onset.

[Molecular Cell] Scientists explained the specificity of the role of BAF subunit actin-like 6a (ACTL6A) amplification in squamous cell carcinomas and demonstrated that ACTL6A overexpression led to its stoichiometric assembly into BAF complexes.

[Nature Immunology] Intestinal epithelial cell (IEC) damage by T cells contributes to graft-versus-host disease, inflammatory bowel disease and immune checkpoint blockade-mediated colitis. The relevance of IEC-intrinsic succinate dehydrogenase A in mediating disease severity was confirmed by complementary chemical and genetic experimental approaches and validated in human clinical samples.