epithelial cells

[Scientific Reports] Investigators used striped catfish to establish an ex vivo skin explant tissue culture model to explore host pathogen interaction. They concluded that this ex vivo skin explant model could serve as a teleost skin infection model for monitoring pathogenesis under various infection conditions.

[Current Biology] Scientists highlight how morphogenetic processes are achieved by cell-shape changes, cell rearrangements, and oriented cell division. They describe approaches that have the potential to engineer 3D tissues for both basic science and translational purposes.

[Proceedings of the National Academy of Sciences of the United States of America] The molecular mechanism by which microbiota-derived ATP in the colon is regulated remains poorly understood. Researchers showed that E-NTPD8 was highly expressed in large-intestinal epithelial cells and hydrolyzed microbiota-derived luminal ATP.

[Journal of Oral Microbiology] Human intestinal epithelial HT-29 cells and esophageal epithelial FLO-1 cells with and without interferon (IFN)-γ sensitization were incubated with C. concisus strains. The level of programmed cell death ligand-1 mRNA was quantified using quantitative real-time PCR.

[Journal of Experimental Medicine] Researchers revealed that in addition to its known regulatory properties in preventing immune hyperactivity, gut epithelial IL-27 confered barrier immunity by inducing a specific intraepithelial lymphocyte subset and further suggested that IL-27 produced by different cell types played distinct roles in maintaining intestinal homeostasis.

[Immunological Reviews] Scientists discuss responses of the epithelium that promote airway immunopathology, with a focus on miRNAs that contribute to the breakdown of essential epithelial functions.