epithelial cells

[Cell Death & Disease] Through unbiased kinome RNAi and drug repurposing screens scientists identified JAK1/2 kinases as the principal and nonredundant drivers of the synergistic killing of human intestinal epithelial cells by IFN-γ/TNF-α.

[Cancer Cell International] Investigators examined the expression of DDR1 in prostate cancer, and assessed its potential value as a prognostic marker, as a function of grade, stage and other clinicopathologic parameters.

[Oncotarget] Scientists performed a 24-hour treatment of a representative carcinogens cocktail in 37 independent organoid lines derived from normal colon biopsies.

[Science Immunology] To decipher immune recognition of human adenoviruse (HAdV) infection and determine new targets for immune-mediated control, researchers used an HAdV infection 3D organoid system, based on primary human intestinal epithelial cells.

[Science Advances] Investigators found that viral infection promoted the G protein–coupled receptor lysophosphatidic acid (LPA)1 expression, and LPA restrained type I/III interferon production through LPA1.

[Nature Communications] Scientists performed an integrative genomic profiling of 163 pediatric liver tumors based on the data acquired from a cohort study. DNA methylation profiling revealed that classical hepatoblastomas were characterized by the specific hypomethylated enhancers, which were enriched with binding sites for ASCL2, a regulatory transcription factor for definitive endoderm in Wnt-pathway.