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epithelial cells

Serum-Derived Exosomes from House Dust Mite-Sensitized Guinea Pigs Contribute to Inflammation in BEAS-2B Cells via the TLR4-NF-κB Pathway

[Molecular Medicine Reports] The authors investigated whether serum exosomes played a pro‑inflammatory role in bronchial epithelial cells and explored the underlying molecular mechanisms.

Electronic Cigarette Smoke Reduces Ribosomal Protein Gene Expression to Impair Protein Synthesis in Primary Human Airway Epithelial Cells

[Scientific Reports] Researchers reported transcriptomic changes, including decreased expression of many ribosomal genes, in airway epithelial cells in response to e-cig exposure.

Role of Aneuploid Circulating Tumor Cells and CD31+ Circulating Tumor Endothelial Cells in Predicting and Monitoring Anti-angiogenic Therapy Efficacy in Advanced NSCLC

[Molecular Oncology] Co-detection and comprehensive phenotypic and karyotypic molecular characterization of aneuploid circulating tumor cells and circulating tumor endothelial cells were conducted on non-small cell lung cancer patients receiving bevacizumab plus chemotherapy.

Diclofenac Down-Regulates COX-2 Induced Expression of CD44 and ICAM-1 in Human HT29 Colorectal Cancer Cells

[Naunyn-Schmiedebergs Archives of Pharmacology] Scientists investigated the effect of diclofenac, a selective COX-2 inhibitor, on cell adhesion molecules and apoptosis in human colon adenocarcinoma cells. Levels of homing cell adhesion molecule, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and epithelial cell adhesion molecule were evaluated in cancer cells overexpressing or not expressing COX-2.

Faciogenital Dysplasia 5 Confers the Cancer Stem Cell-Like Traits of Gastric Cancer Cells through Enhancing Sox2 Protein Stability

[Environmental Toxicology] Faciogenital dysplasia 5 (FGD5) was knocked down in gastric cancer cell lines through two independent siRNAs against FGD5 and it was identified that FGD5 knockdown suppressed the cancer stem cell (CSC)—like traits of gastric cancer cells through analyzing the expression of CSC markers, ALDH1 activity and spheroid-formation ability.

Age-Dependent Regulation of SARS-CoV-2 Cell Entry Genes and Cell Death Programs Correlates with COVID-19 Severity

[Science Advances] Scientists found that mRNA and protein expression of angiotensin-converting enzyme 2, the cell entry receptor for the novel SARS-CoV-2 that causes COVID-19, increases with advancing age in distal lung epithelial cells.

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