Diclofenac Down-Regulates COX-2 Induced Expression of CD44 and ICAM-1 in Human HT29 Colorectal Cancer Cells

Scientists investigated the effect of diclofenac, a selective COX-2 inhibitor, on cell adhesion molecules and apoptosis in human colon adenocarcinoma cells. Levels of homing cell adhesion molecule, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and epithelial cell adhesion molecule were evaluated in cancer cells overexpressing or not expressing COX-2.