Scientists explored the protective effect of vitamin E on chronic obstructive pulmonary disease and the underlying mechanisms.
[zotpress userid=” items=’SPXSDFJC’ style=’apa’ cite=’yes’]
Using DNA-label retaining, single-cell RNA sequencing, and other approaches, researchers investigated intestinal adenoma in response to chemoradiotherapy, thus identifying therapy-resistant tumor-initiating stem cells.
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Scientists investigated the effect of diclofenac, a selective COX-2 inhibitor, on cell adhesion molecules and apoptosis in human colon adenocarcinoma cells. Levels of homing cell adhesion molecule, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and epithelial cell adhesion molecule were evaluated in cancer cells overexpressing or not expressing COX-2.
[Naunyn-Schmiedebergs Archives of Pharmacology]
[zotpress userid=” items=’2J4TWR9S’ style=’apa’ cite=’yes’]
Scientists present a comprehensive overview of the current literature concerning how miRNAs and cyclooxygenase-2 signaling interact in breast cancer progression.
[Clinica Chimica Acta]
[zotpress userid=’7992332′ items=’MZTL9GG2′ style=’apa’ cite=’yes’]
Identified through screening for cancer-specific endogenous retroviral transcripts, scientists showed that the little-studied E3 ubiquitin ligase HECTD2 exerted dominant control of tumor progression in melanoma.
[zotpress userid=’7753456′ items=’5I65XA3V’ style=’apa’ cite=’yes’]
The authors investigated the immunosuppressive and immunomodulation abilities of Withaferin A and its effect on long-term islet allograft survival.
[zotpress userid=” items=’MJQ3BP9M’ style=’apa’ cite=’yes’]
By generating a potentially novel endothelial specific Dgke-knockout mouse, researchers demonstrated that loss of Dgke in the endothelium resulted in impaired signaling downstream of VEGFR2 due to cellular shortage of phosphatidylinositol 4,5-biphosphate.
[zotpress userid=” items=’J6EBIZG8′ style=’apa’ cite=’yes’]
Scientists suggest that valdecoxib alleviated insulin resistance through AMP-activated protein kinase/heat shock protein beta 1-mediated inhibition of inflammation and endoplasmic reticulum stress in skeletal muscle under hyperlipidemic conditions.
[zotpress userid=’6606345′ items=’4G9KSNBB’ style=’apa’ cite=’yes’]
Scientists identified multiple cyclooxygenase 2 (COX-2) associated genes that regulate tumor lung colonization in TNBC. Furthermore, they found that silencing MFGE8 and KLK5/7 gene expression in TNBC cells markedly restored sensitivity to COX-2 selective inhibitor both In Vitro and In Vivo.
[Breast Cancer Research]
[zotpress userid=’6606345′ items=’4SHBK4LS’ style=’apa’ cite=’yes’]
Investigators evaluated the anti-inflammatory properties of coelonin and militarine and examined their underlying molecular mechanisms in A549 cells exposed to PM2.5.
[European Journal of Pharmacology]
[zotpress userid=’6445212′ items=’VWLW3VEF’ style=’apa’ cite=’yes’]
The authors report that a novel mechanism, which contributes to transient receptor potential ion channel, vanilloid subfamily, member 1 (TRPV1) activation-induced TRPV1-sensitization within ~ 30 min in at least ~ 30% of TRPV1-expressing cultured murine primary sensory neurons, was mediated through upregulation in cyclooxygenase 2 (COX2) expression and increased synthesis of a series of COX2 products.
[zotpress userid=’6807162′ items=’LB8RH2Q9′ style=’apa’ cite=’yes’]