Tag Archives: cyclooxygenase-2

Xeno-Free Condition Enhances Therapeutic Functions of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis by Upregulated Indoleamine 2,3-Dioxygenase Activity

Researcchers extensively compared the physiological functions of human Wharton’s jelly-derived mesenchymal stem cells in a xeno-free medium and a medium containing 10% fetal bovine serum.
[Journal of Clinical Medicine]
Kang, J. Y., Oh, M.-K., Joo, H., Park, H. S., Chae, D.-H., Kim, J., Lee, H.-R., Oh, I.-H., & Yu, K.-R. (2020). Xeno-Free Condition Enhances Therapeutic Functions of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis by Upregulated Indoleamine 2,3-Dioxygenase Activity. Journal of Clinical Medicine, 9(9), 2913. https://doi.org/10.3390/jcm9092913 Cite
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Deficiency of the SMOC2 Matricellular Protein Impairs Bone Healing and Produces Age-Dependent Bone Loss

The authors report a patient with a loss-of-function of the secreted matricellular protein SPARC related modular calcium binding 2 (SMOC2) presenting severe oligodontia, microdontia, tooth root deficiencies, alveolar bone hypoplasia, and a range of skeletal malformations.
[Scientific Reports]
Morkmued, S., Clauss, F., Schuhbaur, B., Fraulob, V., Mathieu, E., Hemmerlé, J., Clevers, H., Koo, B.-K., Dollé, P., Bloch-Zupan, A., & Niederreither, K. (2020). Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss. Scientific Reports, 10(1), 14817. https://doi.org/10.1038/s41598-020-71749-6 Cite
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EpCAM Targeted 3WJ RNA Nanoparticle Harboring Delta-5-Desaturase siRNA Inhibited Lung Tumor Formation via DGLA Peroxidation

By incorporating epithelial cell adhesion molecule (EpCAM) aptamer and validated delta-5-desaturase (D5D) siRNA into the innovative three way-junction RNA-nanoparticle, target specific accumulation and D5D knockdown were achieved in the lung cancer cell and mouse models.
[Molecular Therapy-Nucleic Acids]
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The Prostaglandin Synthases, COX-2 and L-PGDS, Mediate Prostate Hyperplasia Induced by Low-Dose Bisphenol A

In vitro studies showed that low-dose bisphenol A promoted the proliferation of human prostate fibroblasts and epithelial cells, and significantly upregulated the expression of cyclooxygenase-2 (COX-2) and L-PGDS in the cells.
[Scientific Reports]
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