Vitamin E Relieves Chronic Obstructive Pulmonary Disease by Inhibiting COX2-Mediated P-STAT3 Nuclear Translocation through the EGFR/MAPK Signaling Pathway

Scientists explored the protective effect of vitamin E on chronic obstructive pulmonary disease and the underlying mechanisms.
[Laboratory Investigation]
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Tumor-Initiating Stem Cell Shapes Its Microenvironment into an Immunosuppressive Barrier and Pro-Tumorigenic Niche

Using DNA-label retaining, single-cell RNA sequencing, and other approaches, researchers investigated intestinal adenoma in response to chemoradiotherapy, thus identifying therapy-resistant tumor-initiating stem cells.
[Cell Reports]
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Diclofenac Down-Regulates COX-2 Induced Expression of CD44 and ICAM-1 in Human HT29 Colorectal Cancer Cells

Scientists investigated the effect of diclofenac, a selective COX-2 inhibitor, on cell adhesion molecules and apoptosis in human colon adenocarcinoma cells. Levels of homing cell adhesion molecule, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and epithelial cell adhesion molecule were evaluated in cancer cells overexpressing or not expressing COX-2.
[Naunyn-Schmiedebergs Archives of Pharmacology]
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MicroRNA and Cyclooxygenase-2 in Breast Cancer

Scientists present a comprehensive overview of the current literature concerning how miRNAs and cyclooxygenase-2 signaling interact in breast cancer progression.
[Clinica Chimica Acta]
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E3 Ubiquitin Ligase HECTD2 Mediates Melanoma Progression and Immune Evasion

Identified through screening for cancer-specific endogenous retroviral transcripts, scientists showed that the little-studied E3 ubiquitin ligase HECTD2 exerted dominant control of tumor progression in melanoma.
[Oncogene]
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Withaferin A Inhibits Lymphocyte Proliferation, Dendritic Cell Maturation In Vitro and Prolongs Islet Allograft Survival

The authors investigated the immunosuppressive and immunomodulation abilities of Withaferin A and its effect on long-term islet allograft survival.
[Scientific Reports]
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Loss of Diacylglycerol Kinase ε Causes Thrombotic Microangiopathy by Impairing Endothelial VEGFA Signaling

By generating a potentially novel endothelial specific Dgke-knockout mouse, researchers demonstrated that loss of Dgke in the endothelium resulted in impaired signaling downstream of VEGFR2 due to cellular shortage of phosphatidylinositol 4,5-biphosphate.
[JCI Insight]
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Valdecoxib Improves Lipid-Induced Skeletal Muscle Insulin Resistance via Simultaneous Suppression of Inflammation and Endoplasmic Reticulum Stress

Scientists suggest that valdecoxib alleviated insulin resistance through AMP-activated protein kinase/heat shock protein beta 1-mediated inhibition of inflammation and endoplasmic reticulum stress in skeletal muscle under hyperlipidemic conditions.
[Biochemical Pharmacology]
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Identification of MFGE8 and KLK5/7 as Mediators of Breast Tumorigenesis and Resistance to COX-2 Inhibition

Scientists identified multiple cyclooxygenase 2 (COX-2) associated genes that regulate tumor lung colonization in TNBC. Furthermore, they found that silencing MFGE8 and KLK5/7 gene expression in TNBC cells markedly restored sensitivity to COX-2 selective inhibitor both In Vitro and In Vivo.
[Breast Cancer Research]
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Inhibition of Inflammation-Induced Injury and Cell Migration by Coelonin and Militarine in PM2.5-Exposed Human Lung Alveolar Epithelial A549 Cells

Investigators evaluated the anti-inflammatory properties of coelonin and militarine and examined their underlying molecular mechanisms in A549 cells exposed to PM2.5.
[European Journal of Pharmacology]
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TRPV1 Feed-Forward Sensitization Depends on COX2 Upregulation in Primary Sensory Neurons

The authors report that a novel mechanism, which contributes to transient receptor potential ion channel, vanilloid subfamily, member 1 (TRPV1) activation-induced TRPV1-sensitization within ~ 30 min in at least ~ 30% of TRPV1-expressing cultured murine primary sensory neurons, was mediated through upregulation in cyclooxygenase 2 (COX2) expression and increased synthesis of a series of COX2 products.
[Scientific Reports]
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