Scientists identified multiple cyclooxygenase 2 (COX-2) associated genes that regulate tumor lung colonization in TNBC. Furthermore, they found that silencing MFGE8 and KLK5/7 gene expression in TNBC cells markedly restored sensitivity to COX-2 selective inhibitor both In Vitro and In Vivo.
[Breast Cancer Research]
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Investigators evaluated the anti-inflammatory properties of coelonin and militarine and examined their underlying molecular mechanisms in A549 cells exposed to PM2.5.
[European Journal of Pharmacology]
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Cheng, W., Lu, J., Wang, B., Sun, L., Zhu, B., Zhou, F., & Ding, Z. (2021). Inhibition of inflammation-induced injury and cell migration by coelonin and militarine in PM2.5-exposed human lung alveolar epithelial A549 cells. European Journal of Pharmacology, 896, 173931. https://doi.org/10.1016/j.ejphar.2021.173931 Cite
The authors report that a novel mechanism, which contributes to transient receptor potential ion channel, vanilloid subfamily, member 1 (TRPV1) activation-induced TRPV1-sensitization within ~ 30 min in at least ~ 30% of TRPV1-expressing cultured murine primary sensory neurons, was mediated through upregulation in cyclooxygenase 2 (COX2) expression and increased synthesis of a series of COX2 products.
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In vitro, over 25 weeks of microcystins-LR exposure, normal human prostate epithelial (RWPE-1) cells increased secretion of matrix metalloproteinase-2, matrix metalloproteinase-9, and colony formation, features typical for cancer cells.
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Pan, C., Zhang, L., Meng, X., Qin, H., Xiang, Z., Gong, W., Luo, W., Li, D., & Han, X. (2021). Chronic exposure to microcystin-LR increases the risk of prostate cancer and induces malignant transformation of human prostate epithelial cells. Chemosphere, 263, 128295. https://doi.org/10.1016/j.chemosphere.2020.128295 Cite
Endothelial cells were exposed to high levels of the cholesterol oxidation product, 7-ketocholesterol, in patients with cardiovascular disease and diabetes, and this process is thought to mediate pathological inflammation.
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Investigators showed that NRF2 suppressed the activity of the melanocyte lineage marker MITF in melanoma, thereby reducing the expression of pigmentation markers.
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Researcchers extensively compared the physiological functions of human Wharton’s jelly-derived mesenchymal stem cells in a xeno-free medium and a medium containing 10% fetal bovine serum.
[Journal of Clinical Medicine]
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Kang, J. Y., Oh, M.-K., Joo, H., Park, H. S., Chae, D.-H., Kim, J., Lee, H.-R., Oh, I.-H., & Yu, K.-R. (2020). Xeno-Free Condition Enhances Therapeutic Functions of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis by Upregulated Indoleamine 2,3-Dioxygenase Activity. Journal of Clinical Medicine, 9(9), 2913. https://doi.org/10.3390/jcm9092913 Cite
The authors report a patient with a loss-of-function of the secreted matricellular protein SPARC related modular calcium binding 2 (SMOC2) presenting severe oligodontia, microdontia, tooth root deficiencies, alveolar bone hypoplasia, and a range of skeletal malformations.
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Morkmued, S., Clauss, F., Schuhbaur, B., Fraulob, V., Mathieu, E., Hemmerlé, J., Clevers, H., Koo, B.-K., Dollé, P., Bloch-Zupan, A., & Niederreither, K. (2020). Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss. Scientific Reports, 10(1), 14817. https://doi.org/10.1038/s41598-020-71749-6 Cite
By incorporating epithelial cell adhesion molecule (EpCAM) aptamer and validated delta-5-desaturase (D5D) siRNA into the innovative three way-junction RNA-nanoparticle, target specific accumulation and D5D knockdown were achieved in the lung cancer cell and mouse models.
[Molecular Therapy-Nucleic Acids]
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In vitro studies showed that low-dose bisphenol A promoted the proliferation of human prostate fibroblasts and epithelial cells, and significantly upregulated the expression of cyclooxygenase-2 (COX-2) and L-PGDS in the cells.
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