The authors report a patient with a loss-of-function of the secreted matricellular protein SPARC related modular calcium binding 2 (SMOC2) presenting severe oligodontia, microdontia, tooth root deficiencies, alveolar bone hypoplasia, and a range of skeletal malformations.
Morkmued, S., Clauss, F., Schuhbaur, B., Fraulob, V., Mathieu, E., Hemmerlé, J., Clevers, H., Koo, B.-K., Dollé, P., Bloch-Zupan, A., & Niederreither, K. (2020). Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss. Scientific Reports, 10(1), 14817. https://doi.org/10.1038/s41598-020-71749-6Cite
By incorporating epithelial cell adhesion molecule (EpCAM) aptamer and validated delta-5-desaturase (D5D) siRNA into the innovative three way-junction RNA-nanoparticle, target specific accumulation and D5D knockdown were achieved in the lung cancer cell and mouse models.
In vitro studies showed that low-dose bisphenol A promoted the proliferation of human prostate fibroblasts and epithelial cells, and significantly upregulated the expression of cyclooxygenase-2 (COX-2) and L-PGDS in the cells.