epithelial cells

[EMBO Molecular Medicine] Using mouse mammary tissue ex vivo, scientists showed that testosterone-related progestins induced the progesterone receptor (PR) target and mediator of PR signaling-induced cell proliferation receptor activator of NF-κB ligand, whereas progestins with anti-androgenic properties in reporter assays did not.

[Scientific Reports] Scientists studied the biological function of cytoplasmic maspin in breast cancer cell lines. Subcellular localization of maspin in MDA-MB-231 breast cancer cells was mainly detected in the cytoplasm, whereas in MCF10A mammary epithelial cells, maspin was present in both cytoplasm and nucleus.

[Cell Death & Disease] Researchers analyzed colonic tissue samples from patients with ulcerative colitis (UC) and constructed specific intestinal epithelial phenazine biosynthesis-like domain-containing protein (PBLD)-deficient mice to investigate the role of this protein in UC pathogenesis.

[integrative Biology] The clustering of integrin α5ß1 at the plasma membrane of colorectal cancer-derived epithelial cells modulated their ability to respond to stimulation by receptor tyrosine kinase-activating growth factors EGF, NRG and HGF, through GSK3-mediated suppression of Akt pathway.

[Journal of Biological Chemistry] Scientists examined the relationship of RAB11A to epithelial junctional complexes, YAP, and the associated consequences on colonic epithelial tissue repair.

[Proceedings of the National Academy of Sciences of the United States of America] Cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) deficiency led to intestinal stem cell loss and compromised intestinal barrier integrity upon dextran sodium sulfate-induced acute injury.