extracellular matrix

[GeroScience] Researchers reanalyzed existing RNA-seq data, comparing the transcriptome in the aorta arch samples isolated from isochronic parabiont aged C57BL/6 mice.

[Aging and Disease] The authors discuss the underlying pathogenesis of irreversible pulmonary fibrosis as well as preclinical disease models, and also suggest directions for future studies.

[NPJ Regenerative Medicine] Isolated matrix-bound nanovesicles (MBV) were delivered via intravenous or peri-articular injection to rats with pristane-induced arthritis. The results of MBV administration were compared to intraperitoneal administration of methotrexate, the clinical standard of care.

[Cell Reports] Investigators found that pregnancies in mice with EZH2-deficient decidual stromal cells frequently failed by mid-gestation, with the decidua showing ectopic myofibroblast formation, peri-embryonic collagen deposition, and gene expression profiles associated with transforming growth factor β (TGF-β)-driven fibroblast activation and fibrogenic ECM remodeling.

[Journal of Proteomics] The authors studied the proteome profiled of canine native and decellularized placenta to characterize the proteome related to maintenance of a microenvironment and structure suitable for tissue engineering applications.

[Journal of Hepatology] The authors reported that HCV infection was favored by heparanase-1 (HPSE), and upregulated HPSE expression and secretion, which may have resulted in potentially pathogenic alterations of the extracellular matrix.