Gene Silencing by EZH2 Suppresses TGF-β Activity within the Decidua to Avert Pregnancy-Adverse Wound Healing at the Maternal-Fetal Interface

Investigators found that pregnancies in mice with EZH2-deficient decidual stromal cells frequently failed by mid-gestation, with the decidua showing ectopic myofibroblast formation, peri-embryonic collagen deposition, and gene expression profiles associated with transforming growth factor β (TGF-β)-driven fibroblast activation and fibrogenic ECM remodeling.