extracellular matrix

[Cell Stem Cell] Scientists profiled scarring versus YAP-inhibition-induced wound regeneration at the transcriptional, protein, and tissue levels, and showed that disrupting YAP mechanotransduction yielded regenerative repair by fibroblasts with activated Trps1 and Wnt signaling.

[Scientific Reports] Researchers described a possible mechanism involved in skin aging focusing on the effect of Trehangelins on epidermal cellular communication metwork factor 1 (CCN1).

[Journal of Reproductive Immunology] Scientists ascertained the expression of tissue factor in HTR-8/SVneo trophoblast cell line and its role in signal transduction of integrin regulation concerning the invasion of trophoblasts.

[FASEB Journal] Using single-cell RNA-seq, scientists identified macrophages as a source of matrix metalloproteinase 14 in muscle following a hypertrophic exercise stimulus in mice.

[npj Breast Cancer] Scientists showed that reverting the high LIP/LAP ratios in TNBC cell lines into low LIP/LAP ratios by overexpression of LAP reduced migration and matrix invasion of these TNBC cells.

[Scientific Reports] The authors investigated subretinal fibrosis in the laser photocoagulation model of choroidal neovascularization (CNV) by studying the whole transcriptome of the retinal pigment epithelium/choroid following CNV and the application of an anti-fibrotic following CNV.