Transcriptomic Analysis of Choroidal Neovascularization Reveals Dysregulation of Immune and Fibrosis Pathways That Are Attenuated by a Novel Anti-fibrotic Treatment

The authors investigated subretinal fibrosis in the laser photocoagulation model of choroidal neovascularization (CNV) by studying the whole transcriptome of the retinal pigment epithelium/choroid following CNV and the application of an anti-fibrotic following CNV.