extracellular matrix

[Biomaterials] Human primary hepatocyte organoids and HepaRG spheroids showed more mature hepatocyte phenotype after adding fibronectin and fibrinogen to the culture system.

[Science Advances] The development of a bioactive nanocomplex formed along with polydeoxyribonucleotide and bone morphogenetic protein 2 (BMP2) provided synergistic abilities in angiogenesis and bone regeneration.

[Current Biology] Hypoxia-induced amoeboid dissemination occurred through low ECM-adhesive, predominantly bleb-based amoeboid movement, which was maintained by a low-oxidative and -glycolytic energy metabolism.

[Artificial Organs] Investigators describe the decellularization and sterilization methods that are commonly used in recent research, and the effects of these methods upon biologic scaffold material.

[Molecular Cancer Research] Scientists observed that expression of a construct derived from the N-terminus of Stx4, which interfered with Stx4-Munc18c interaction, led to perturbed trafficking of MT1-MMP, and reduced invadopodium-based invasion in vitro, in models of TNBC.

[Biomaterials] Scientists address the role of matrix mellanoproteinases (MMPs) in stem cell differentiation by assaying MMP expression and activity during differentiation of mouse ESCs on mouse embryonic fibroblast derived matrices of varying stiffness and composition.