Syntaxin4-Munc18c Interaction Promotes Breast Tumor Invasion and Metastasis by Regulating MT1-MMP Trafficking

Scientists observed that expression of a construct derived from the N-terminus of Stx4, which interfered with Stx4-Munc18c interaction, led to perturbed trafficking of MT1-MMP, and reduced invadopodium-based invasion in vitro, in models of TNBC.