Identification of the SRC-Family Tyrosine Kinase HCK as a Therapeutic Target in Mantle Cell Lymphoma

Investigators showed that the SRC-family tyrosine kinase hematopoietic cell kinase (HCK), which is primarily expressed in the hematopoietic lineage but not in mature B cells, was aberrantly expressed in mantle cell lymphoma (MCL), and that high expression of HCK was associated with inferior prognosis of MCL patients.
[Leukemia]
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Bioactive‐Tissue‐Derived Nanocomposite Hydrogel for Permanent Arterial Embolization and Enhanced Vascular Healing

A decellularized cardiac extracellular matrix‐based nanocomposite hydrogel was developed to provide superior mechanical stability, catheter injectability, retrievability, antibacterial properties, and biological activity to prevent recanalization.
[Advanced Materials]
Hu, J., Altun, I., Zhang, Z., Albadawi, H., Salomao, M. A., Mayer, J. L., Hemachandra, L. P. M. P., Rehman, S., & Oklu, R. (n.d.). Bioactive-Tissue-Derived Nanocomposite Hydrogel for Permanent Arterial Embolization and Enhanced Vascular Healing. Advanced Materials, n/a(n/a), 2002611. https://doi.org/10.1002/adma.202002611 Cite
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A Scaffold Laden with Mesenchymal Stem Cell-Derived Exosomes for Promoting Endometrium Regeneration and Fertility Restoration through Macrophage Immunomodulation

A novel and viable cell-free therapeutic strategy by umbilical cord-MSC-derived exosomes was proposed.
[Acta Biomaterialia]
Xin, L., Lin, X., Zhou, F., Li, C., Wang, X., Yu, H., … Zhang, S. (2020). A scaffold laden with mesenchymal stem cell-derived exosomes for promoting endometrium regeneration and fertility restoration through macrophage immunomodulation. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2020.06.029 Cite
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Switch of Macrophage Fusion Competency by 3D Matrices

Scientists introduced a collagen-based 3D matrix to embed Raw264.7 cell line and primary rat bone marrow-derived macrophages.
[Scientific Reports]
Fang, J. Y., Yang, Z., & Han, B. (2020). Switch of macrophage fusion competency by 3D matrices. Scientific Reports, 10(1), 10348. https://doi.org/10.1038/s41598-020-67056-9 Cite
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A Flowable Placental Formulation Prevents Bleomycin-Induced Dermal Fibrosis in Aged Mice

Researchers investigated the anti-fibrotic activity of a flowable placental formulation using a bleomycin-induced dermal fibrosis model in aged mice.
[European Journal of Human Genetics]
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Proteomic Profiling of Striatal Tissue of a Rat Model of Parkinson’s Disease after Implantation of Collagen-Encapsulated Human Umbilical Cord Mesenchymal Stem Cells

Human umbilical cord-MSCs were encapsulated into collagen hydrogels and implanted into the striatum of hemi‐parkinsonian male Sprague Dawley rats. One or 14 days after implantation, the area of interest was dissected using a cryostat.
[Journal of Tissue Engineering and Regenerative Medicine]
Santaella, A., Wessels, H. J. C. T., Kulkarni, P., Gloerich, J., Kuiperij, H. B., Bloem, B. R., … Verbeek, M. M. (n.d.). Proteomic profiling of striatal tissue of a rat model of Parkinson’s disease after implantation of collagen-encapsulated human umbilical cord mesenchymal stem cells. Journal of Tissue Engineering and Regenerative Medicine, n/a(n/a). https://doi.org/10.1002/term.3081 Cite
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Allosteric Communications between Domains Modulate the Activity of Matrix Metalloprotease-1

Investigators showed that communications between the catalytic and hemopexin domains of matrix metalloprotease-1 on type-1 collagen fibrils correlated with its activity.
[Biophysical Journal]
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LiQD Cornea: Pro-Regeneration Collagen Mimetics as Patches and Alternatives to Corneal Transplantation

The self-assembling, fully defined, synthetic collagen analog is much less costly than human recombinant collagen and reduced the risk of immune rejection associated with xenogeneic materials.
[Science Advances]
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Humidity‐Triggered Relaxation of Polyelectrolyte Complexes as a Robust Approach to Generate Extracellular Matrix Biomimetic Films

Scientists report a facile approach to generate ECM biomimetic films based on the humidity‐triggered relaxation of polyelectrolyte complex nanoparticles.
[Advanced Healthcare Materials]
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Regulation of Heterogeneous Cancer-Associated Fibroblasts: The Molecular Pathology of Activated Signaling Pathways

Pro-inflammatory cytokines, such as leukemia inhibitory factor and interleukin-6, were secreted by both cancer cells and cancer associated fibroblasts (CAFs), and mediated the epigenetic modification of CAFs. This enhanced the pro-tumorigenic function of CAFs mediated by promoting actomyosin contractility and ECM remodeling to form the tracks used for collective cancer cell migration.
[Journal of Experimental & Clinical Cancer Research]
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Simulating the Human Colorectal Cancer Microenvironment in 3D Tumor-Stroma Co-Cultures In Vitro and In Vivo

Researchers successfully converted three in-house-derived primed human PSC lines to a naive state and an expanded pluripotent stem cell (EPS) state. Primed, naive and EPS cells displayed state-specific morphologies and expressed pluripotent markers.
[Scientific Reports]
Devarasetty, M., Dominijanni, A., Herberg, S., Shelkey, E., Skardal, A., & Soker, S. (2020). Simulating the human colorectal cancer microenvironment in 3D tumor-stroma co-cultures in vitro and in vivo. Scientific Reports, 10(1), 9832. https://doi.org/10.1038/s41598-020-66785-1 Cite
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