extracellular matrix

[Nature Communications] The authors investigated mature human hypertrophic scars and developing scars in mice at single cell resolution. They delineated the genetic landscape of hypertrophic scars and presented insights into mechanisms involved in hypertrophic scar formation.

[Scientific Reports] Investigators explored breast cancer and glioblastoma multiforme cell lines MDA-MB-321 and U87-MG, and evaluated the impact of hyaluronan on tumor promoting features of bone marrow-derived mesenchymal stem cells, and their interaction with tumor cells.

[Cell Death Discovery] The authors indicated that RCAN1.4 expression was impaired both in unilateral ureteral obstruction-induced renal fibrosis in vivo and TGF-β1-induced renal fibrosis in vitro. However, knocking in of RCAN1.4 suppressed the production of ECM both in vivo and in vitro.

[Biomaterials Science] Chondrocytes seeded within a a dual crosslinked pullulan-gelatin cryogel scaffold and cultured for 21 days in vitro demonstrated enhanced cell proliferation, enhanced production of cartilage-specific ECM and up-regulated sulfated glycosaminoglycan without altering the articular chondrocyte phenotype.

[Advanced Healthcare Materials] The authors summarize the two major nanomedicine strategies to circumvent intratumor ECM barriers: regulating the physiochemical properties of nanomedicines and remodeling the components and structure of the ECM.

[Nature Communications] Researchers developed a material and culture system for modifying and measuring the degree to which cells retained cumulative effects of mechanosensing.