RCAN1.4 Attenuates Renal Fibrosis through Inhibiting Calcineurin-Mediated Nuclear Translocation of NFAT2

The authors indicated that RCAN1.4 expression was impaired both in unilateral ureteral obstruction-induced renal fibrosis in vivo and TGF-β1-induced renal fibrosis in vitro. However, knocking in of RCAN1.4 suppressed the production of ECM both in vivo and in vitro.