Dual Crosslinked Pullulan-Gelatin Cryogel Scaffold for Chondrocyte-Mediated Cartilage Repair: Synthesis, Characterization and In Vitro Evaluation

Chondrocytes seeded within a a dual crosslinked pullulan-gelatin cryogel scaffold and cultured for 21 days in vitro demonstrated enhanced cell proliferation, enhanced production of cartilage-specific ECM and up-regulated sulfated glycosaminoglycan without altering the articular chondrocyte phenotype.