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fibroblasts

Sebocytes Contribute to Melasma Onset

[iScience] To explore the sebaceous glands' possible contribution to melasma onset, the expression of pro-melanogenic and inflammatory factors from the SZ95 SG cell line exposed to single or repetitive ultraviolet A radiation was evaluated.

Development of a Skin- and Neuro-Attenuated Live Vaccine for Varicella

[Nature Communications] A rationally design a live-attenuated varicella vaccine candidate, v7D, showed immunogenicity comparable to vOka both in vitro and in multiple small animal species.

Complement C5aR/LPS-Induced BDNF and NGF Modulation in Human Dental Pulp Stem Cells

[Scientific Reports] Scientists compared the neurogenic ability of dental pulp stem cells to bone marrow-derived MSCs under inflammatory stimulation.

Therapeutic Effects of Eperisone on Pulmonary Fibrosis via Preferential Suppression of Fibroblast Activity

[Cell Death Discovery] Researchers used a library containing approved drugs to screen for drugs that preferentially reduce cell viability in lung fibroblasts from an IPF patient compared with a human alveolar epithelial cell line.

NF-κB Perturbation Reveals Unique Immunomodulatory Functions in Prx1+ Fibroblasts That Promote Development of Atopic Dermatitis

[Science Translational Medicine] Investigators examined human atopic dermatitis (AD) skin samples and found that human AD fibroblasts also overexpressed C-C motif chemokine ligand 11 (CCL11) and that perturbation of Ikkb–NF-κB in primary human dermal fibroblasts up-regulated CCL11.

The Influence of CD26+ and CD26− Fibroblasts on the Regeneration of Human Dermo-Epidermal Skin Substitutes

[Scientific Reports] Researchers investigated the impact of CD26 deficiency in human primary fibroblasts on the regeneration of human tissue-engineered skin substitutes in vivo.

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