fibroblasts

[Journal of Physiology and Biochemistry] Scientists identified that a 3D co-culture model of MIA PaCa-2 or PANC-1 with cancer-associated fibroblasts showed an increased chemoresistance to gemcitabine when compared to standard 2D mono-cultures a difference to paclitaxel which showed no measurable difference between the 2D and 3D models, suggesting a complex interaction between the drug in study and the cell type used.

[Journal of Clinical Investigation] Investigators described two siblings with recurrent skin ulcers that healed with scar formation upon corticosteroid treatment and characterized ISG15-/- dermal fibroblasts, HaCaT keratinocytes, and human induced pluripotent stem cell-derived vascular endothelial cells.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] To address limitations in cell culture and in vivo mechanotransductive models, scientists developed two mouse lung organoid mechanotransductive models using postnatal day five mouse lung CD326-positive cells and fibroblasts subjected to increased, decreased, and cyclic strain.

[Cell Death & Disease] Scientists compared the effects of cancer-associated fibroblasts (CAFs)-derived exosomes and normal fibroblasts (NFs)-derived exosomes on breast cancer cells migration and invasion and showed that CAFs-derived exosomes had a more enhancing effect on breast cancer cells migration and invasion than NFs-derived exosomes.

[Acta Pharmacologica Sinica] In vitro, scientists found that DAPA inhibited the expression of cleaved caspase 3, Bax, C/EBP homologous protein (CHOP), and glucose-regulated protein78 (GRP78) and upregulated the cardiomyoprotective protein Bcl-2 in angiotensin II (Ang II)-treated cardiomyocytes.

[Human Immunology] The authors reviewed the molecular mechanisms and the role of immune cells and responses involved in pulmonary hypertension development.