fibroblasts

[npj Parkinson's Disease] To detect potential effects of different glucose levels on gene expression, by RNA-seq researchers analyzed the transcriptome of dermal fibroblasts from idiopathic Parkinson’s disease (PD) patients, LRRK2-associated PD patients, and healthy controls, cultured at two different glucose concentrations.

[NPJ Regenerative Medicine] To establish a well-defined 3D cell culture model to mimic the tissue repair process, researchers utilized THP-1 human monocytic cells and a 3D collagen matrix as a biomimetic tissue model.

[Journal of Molecular and Cellular Cardiology] Investigators demonstrated marker expression and matrix competency of cardiac fibroblasts developed through a developmentally conserved epicardial pathway as shown next to primary human cardiac fibroblasts.

[Proceedings of the National Academy of Sciences of the United States of America] For key structural factors within the nucleus and ECM, the authors discovered specific gene-gene scaling exponents across many of the 32 tumor types in The Cancer Genome Atlas, and they demonstrated utility in predicting patient survival as well as scaling-informed machine learning.

[Biomedicine & Pharmacotherapy] Researchers demonstrated that polymethoxyflavones purified from K. parviflora rhizomes suppressed cellular senescence, reactive oxygen species, and the senescence-associated secretory phenotype in primary human dermal fibroblasts.

[Nanomedicine-Nanotechnology Biology and Medicine] Multifunctional bilayered dermal patches with antibacterial, antioxidant and anti-inflammatory properties were developed and compared for performance. Soluble eggshell membrane protein improved migration of human adult dermal fibroblasts, suggesting its contribution to wound healing.