gastric cancer

[Journal of Cellular Biochemistry] MiR-1290 was discovered for the first time in human embryonic stem cells, and under typical physiological situations, plays an essential role in neuronal differentiation and neural stem cell proliferation.

[Journal of Medicinal Chemistry] AL-GDa62 preferentially induced apoptosis in CDH1–/– cells, and Cdh1–/– mammary and gastric organoids were significantly more sensitive to AL-GDa62 at low micromolar concentrations.

[Small] A self-assembled heterodimer consisting of clustered regularly interspaced short palindromic repeats/Cas12a linkage was designed for in situ identification and screening of gastric CSCs from gastric cancer cells.

[Nature Cell Biology] Scientists showed that Cldn18 tumors accurately recapitulated advanced human gastric cancer in terms of disease morphology, aberrant gene expression, molecular markers and sites of distant metastases.

[Cell Death & Disease] Sphere-formation assay was used to estimate the stemness of gastric cancer stem cells. Exosomal lnc-ENDOG-1:1 (lncFERO) was isolated by ultracentrifugation.

[Cellular Oncology] The effect of BET inhibition was evaluated using iBET-151, a small-molecule inhibitor of BET proteins, in a large panel of gastric cancer cell lines and xenograft mouse models. The synergistic effect of iBET-151 and paclitaxel was evaluated using an organoid model.