Inhibition of the Bromodomain and Extra-Terminal Family of Epigenetic Regulators as a Promising Therapeutic Approach for Gastric Cancer

The effect of BET inhibition was evaluated using iBET-151, a small-molecule inhibitor of BET proteins, in a large panel of gastric cancer cell lines and xenograft mouse models. The synergistic effect of iBET-151 and paclitaxel was evaluated using an organoid model.