gene knockout

[Autophagy] Scientists report that zinc oxide nanoparticles can induce ferroptosis of both HUVECs and EA.hy926 cells, as evidenced by the elevation of intracellular iron levels, lipid peroxidation and cell death in a dose- and time-dependent manner.

[Hepatology] Scientists identified aldolase A (ALDOA), a key enzyme in glycolysis and gluconeogenesis, as an essential driver for HCC cell growth under hypoxia.

[Scientific Reports] CD19-Cre and Mb1-iCre transgenic mice were commonly used for generating B cell-specific KO mice and investigate the development, as well as the physiological and pathophysiological roles of B cells.

[Breast Cancer Research] Scientists identified multiple cyclooxygenase 2 (COX-2) associated genes that regulate tumor lung colonization in TNBC. Furthermore, they found that silencing MFGE8 and KLK5/7 gene expression in TNBC cells markedly restored sensitivity to COX-2 selective inhibitor both In Vitro and In Vivo.

[Cell Death & Disease] Researchers evaluated the hepatoprotective role and mechanism of Withaferin A in D-galactosamine/lipopolysaccharide-induced fulminant hepatitis.

[Apoptosis] Scientists determined the role of autophagy in apoptosis and the generation of immunogenic signals using murine wild-type B16-F10 melanoma cells and cells with beclin-1 gene knockout.