glioblastoma stem cells

[Nature Communications] Scientists used a “two cell type” whole genome CRISPR-Cas9 screening system to discover key regulators of tumor sensitivity and resistance to natural killer cell-mediated cytotoxicity in human glioblastoma stem cells.

[Stem Cells and Development] Researchers established patient derived glioblastoma stem cells (GSCs), determined cancer stem cell marker expression, and immunostained GSCs to assess cell viability and apoptosis.

[Molecular Therapy] The authors reported that FOSL1, a component of activator protein 1 transcription factor complexes, was a key player in regulating proneural-to-mesenchymal transition.

[Molecular Therapy] Researchers reported that FOSL1, a component of AP-1 transcription factor complexes, was a key player in regulating PMT. FOSL1 was predominantly expressed in the mesenchymal subtype, but not proneural subtype of glioblastoma stem cells.

[Molecular Oncology] The glioblastoma tumoral mass was characterized by a small cellular subpopulation, glioblastoma stem cells that has been held responsible for glioblastoma initiation, cell invasion, proliferation, relapse and resistance to chemo and radiotherapy.

[Angiogenesis] Scientists dissected vascular cues influencing glioblastoma stem cells (GSCs) gene expression and function to perfusion-based vascular cues, as well as to those requiring direct GSC-endothelial cell contacts.