glioblastoma

[Journal of Clinical Investigation] The authors showed that glioblastoma stem cells, but not normal astrocytes, were sensitive to lysis by healthy allogeneic natural killer cells in vitro.

[Nature Communications] Scientists generated p32 chimeric antigen receptors (CAR) T cells and found them to recognize and specifically eliminate p32 expressing glioma cells and tumor derived endothelial cells in vitro and to control tumor growth in orthotopic syngeneic and xenograft mouse models.

[Biomedicine & Pharmacotherapy] Scientists investigated protein L-isoaspartyl (D-aspartyl) methyltransferase role in U-87 MG cell viability, adhesion, migration, invasion, and colony formation and in the reorganization of the actin and tubulin cytoskeleton.

[Scientific Reports] Researchers identified 112 up-regulated proteins and 24 down-regulated proteins from a total of 4360 quantified proteins. GO enrichment illustrated that these proteins were mainly involved in organelle structure, catalysis, cell movement, and material metabolism.

[Communications Biology] Using glioblastoma patient-derived stem cells, researchers identified and characterized a subset of Gal-3high glioblastoma tumors mainly within the mesenchymal subtype that are addicted to Gal-3-mediated macropinocytosis.

[Science Advances] To investigate whether H3K27M was associated with distinct chromatin structure that altered transcription regulation, investigators generated the first high-resolution genome structure maps of pediatric high-grade gliomas cell lines and tumor tissue.