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Pulmonary Cell NewsScientists generated p32 chimeric antigen receptors (CAR) T cells and found them to recognize and specifically eliminate p32 expressing glioma cells and tumor derived endothelial cells in vitro and to control tumor growth in orthotopic syngeneic and xenograft mouse models.
[Nature Communications]
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Rousso-Noori, L., Mastandrea, I., Talmor, S., Waks, T., Globerson Levin, A., Haugas, M., Teesalu, T., Alvarez-Vallina, L., Eshhar, Z., & Friedmann-Morvinski, D. (2021). P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas. Nature Communications, 12(1), 3615. https://doi.org/10.1038/s41467-021-23817-2 Cite
