glioblastoma

[Journal of Neuro-Oncology] Researchers examined CD97 function in primary patient-derived glioma stem cells obtained from five glioblastoma tumors, belonging to three major genetic subtypes.

[Molecular Neurobiology] The safety and feasibility of using bone marrow–derived MSCs in combination with prodrug for treatment of patients with primary and secondary glioblastoma multiform was assessed.

[Oncogene] Investigators present SFRP2 as a SOX2-antagonist with the capacity to induce a mesenchymal subtype transition in glioma cells located in vascular tumor areas, highlighting its role in glioblastoma tumor evolution and intratumoral heterogeneity.

[Cell Death & Disease] Investigators demonstrated that Arrb2 interacted with HIF-1α and stimulated ubiquitin-mediated 26S proteasomal degradation of HIF-1α by recruiting PHD2 and pVHL.

[JCI Insight] Researchers reported CD109/STAT3 axis as crucial for the maintenance of stemness and tumorigenicity of glioma stem cells and as a mediator of chemoresistance.

[Nmr in Biomedicine] Dynamic nuclear polarization‐magnetic resonance imaging chemical shift imaging with hyperpolarized [1‐13C] pyruvate was conducted to evaluate the metabolic change in glycolytic profiles after radiation of two glioma stem‐like cell‐derived gliomas and an adherent human glioblastoma cell line in an orthotopic xenograft mouse model.