glioblastoma

[Journal of Experimental & Clinical Cancer Research] Analysis of RNA sequencing and qRT-PCR revealed that miR-3189 increased and GLUT3 decreased by histone deacetylase 2 (HDAC2) knockdown.

[Cancer Research] Researchers explored the potential of antisense oligonucleotides (ASO)-based pyruvate kinase (PKM) splice switching as a targeted therapy for liver cancer. A more potent lead constrained-ethyl/DNA ASO induced PKM splice switching and inhibited the growth of cultured HCC cells.

[Cancer Letters] Scientists identified the gene amplification and protein overexpression of HOXA5 in glioma stem cells (GSCs) and its function in regulating GSC maintenance and the downstream transcriptional effector, to explore the significance of HOXA5 amplification/overexpression for GSC identification and prognostic determination.

[Molecular Oncology] The glioblastoma tumoral mass was characterized by a small cellular subpopulation, glioblastoma stem cells that has been held responsible for glioblastoma initiation, cell invasion, proliferation, relapse and resistance to chemo and radiotherapy.

[Scientific Reports] Nine compounds demonstrated desirable glioblastoma cell toxicity in cell culture, and two of them, HR51, and HR59 demonstrated significantly improved capability of crossing the model blood–brain-barrier composed of endothelial cells, astrocytes and pericytes.

[Biomedicine & Pharmacotherapy] Scientists provide recent findings and insights about miRNAs' angioregulatory role and exosomal miRNAs in glioblastoma.