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graft-versus-host disease

NFAT Signaling in Human Mesenchymal Stromal Cells Affects Extracellular Matrix Remodeling and Anti-Fungal Immune Responses

[iScience] RNA-sequencing analysis of zymosan-treated MSCs showed that calcineurin-NFAT inhibition affects extracellular matrix genes, but not cytokine expression that is under the control of the NF-κB pathway.

COVID-19 and Stem Cell Transplantation; Results from an EBMT and GETH Multicenter Prospective Survey

[Leukemia] The authors reported on 382 COVID-19 patients having undergone allogeneic or autologous hematopoietic cell transplantation reported to the European Society for Blood and Marrow Transplantation (EBMT) or to the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH).

Allogeneic Stem Cell Transplantation for AML Patients with RUNX1 Mutation in First Complete Remission: A Study on Behalf of the Acute Leukemia Working Party...

[Bone Marrow Transplantation] Researchers performed a retrospective, registry-based analysis to elucidate the prognostic value of runt-related transcription factor 1 (RUNX1) mutation after allogeneic stem cell transplantation for AML patients.

Severe Infections and Infection-Related Mortality in a Large Series of Haploidentical Hematopoietic Stem Cell Transplantation with Post-transplant Cyclophosphamide

[Bone Marrow Transplantation] Investigators reported 236 adult patients who received haploidentical HSC transplantation with post-transplant cyclophosphamide.

Prolonged Suppression of Butyrate Producing Bacteria Is Associated with Acute Gastrointestinal Graft-versus-Host Disease and Transplant Related Mortality after Allogeneic Stem Cell Transplantation

[Clinical infectious Diseases] Scientists examined the abundance and butyrogenic capacity of butyrate producing bacteria in 28 healthy donors and 201 patients after allogeneic stem cell transplantation.

Low-Dose Antithymocyte Globulin plus Low-Dose Posttransplant Cyclophosphamide Combined with Cyclosporine and Mycophenolate Mofetil for Prevention of Graft-versus-Host Disease after HLA-Matched Unrelated Donor Peripheral Blood...

[Bone Marrow Transplantation] To improve the efficiency of graft-versus-host disease (GvHD) prophylaxis in matched unrelated donor peripheral blood stem cell transplantation, 51 patients with hematological malignancies received a novel regimen for GvHD prophylaxis composed of low dose antithymocyte globulin.

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