granulocytes

[Immune-Onc Therapeutics, Inc.] Immune-Onc Therapeutics, Inc. announced that the first patient has been dosed in the company’s first-in-human clinical trial of IO-108, a novel antagonist antibody targeting the myeloid checkpoint Leukocyte Immunoglobulin-Like Receptor B2 (LILRB2) for the treatment of solid tumors.

[Pediatric Research] Hemangioma endothelial cells were co-cultured with propranolol-treated HMC-1s supernatants, and their proliferation and apoptosis were investigated.

[Scientific Reports] An eight-color antibody panel was used to identify seven monocyte and two dendritic cell subsets. In the learning cohort, immunophenotyping was applied to control subjects, postoperative heart surgery patients, as a model of noninfectious inflammatory responses, and blood culture-positive patients.

[Blood Advances] The authors adopted CIBERSORTx to estimate the relative fractions of 22 subtypes of immune cells in the bone marrow of 316 myelodysplastic syndrome patients and correlated the results with clinical outcomes.

[Cellular Signalling] The authors revealed the mechanism of neutrophil extracellular traps generation and their role in trophoblast apoptosis in gestational diabetes mellitus.

[Oncogene] Scientists showed that CCL11 was involved in the pathogenesis of dextran sulfate sodium (DSS)-induced colitis and in colon tumorigenesis in the azoxymethane-DSS model of colitis-associated carcinogenesis.