hematopoietic stem cells

[Blood Advances] Researchers showed that hapln1b, a key component of the extracellular matrix was specifically expressed in hematopoietic sites in the zebrafish embryo. Gain- and loss-of-function experiments all resulted in the absence of hematopoietic stem and progenitor cells (HSPCs) in the early embryo, showing that hapln1b was required, at the correct level, to specify HSPCs in the hemogenic endothelium.

[npj Aging and Mechanisms of Disease] Researchers examined the effect of elevating NAD+ levels in models with reduced HSC potential, ATM-deficient and aged WT mice, and showed that supplementation of nicotinamide riboside, a NAD+ precursor, improved lymphoid lineage potential during supplementation.

[Stem Cell Reports] Investigators identified the tetraspanin CD82 as a novel regulator of hematopoietic stem and progenitor cell (HSPC) mobilization. Combining AMD3100 and anti-CD82 treatments, they detected enhanced mobilization of mouse HSPCs and human CD34+ cells in animal models.

[Antioxidants & Redox Signaling] Researchers examined the hematopoietic versus non-hematopoietic role of p66Shc in regulating hematopoietic stem/progenitor cells traffic and blood flow recovery after ischemia in diabetic mice.

[Wiley Interdisciplinary Reviews-RNA] Scientists review the current knowledge of miRNAs function in different aspects of HSC biology, including consequences of aberrant miRNA expression, and discuss unsolved issues.

[Bone Marrow Transplantation] The authors review current critical points of hematopoietic stem cell transplantation using alternative donors and assessing recently reported safety issues of gene therapy methods, and conclude that, although a breakthrough, the safety of gene therapy remains to be established.