hematopoietic stem cells

[Blood Cancer Journal] The authors found that interleukin-10 receptor (IL-10R) was overexpressed in most acute myeloid luekemia cells, and played an important role in promoting the stemness of leukemia cells.

[Blood] Researchers sorted 12 murine adult hematopoietic cell populations at different stages and identified 30,796 editing sites through RNA sequencing. While the dynamic landscape of the RNA editome comprised of stage/group-specific and stable editing patterns, but it also underwent significant changes during lineage commitment..

[Gene Therapy] CAR T cells were designed using a ligand binding domain instead of a single chain variable fragments to target stem-like leukemia cells. Thrombopoietin, the natural ligand to the myeloproliferative leukemia protein (MPL) receptor, was used as the antigen binding domain to engage MPL expressed on HSCs and erythropoietic and megakaryocytic acute myeloid leukemias.

[Leukemia] The increased stemness of acute myeloid leukemia (AML) cells promoted by Tregs was verified in vitro and in vivo, and researchers found that blocking the interaction between Tregs and AML cells may be a new approach to target leukemia stem cells in AML treatment.

[Medexus Pharmaceuticals, Inc.] Medexus Pharmaceuticals, Inc. announced that is has completed enrollment in its Phase IV Clinical Trial of IXINITY®, targeting label expansion for pediatric hemophilia B patients.

[Aging-Us] Researchers compared the gene expression profiles of HSCs in ex vivo expanded serum and serum-free culture systems and analyzed the molecular functions of differentially expressed genes using microarray chips.