The authors found that interleukin-10 receptor (IL-10R) was overexpressed in most acute myeloid luekemia cells, and played an important role in promoting the stemness of leukemia cells.
[Blood Cancer Journal]
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Chen, N., Xu, Y., Mou, J., Rao, Q., Xing, H., Tian, Z., Tang, K., Wang, M., & Wang, J. (2021). Targeting of IL-10R on acute myeloid leukemia blasts with chimeric antigen receptor-expressing T cells. Blood Cancer Journal, 11(8), 1–11. https://doi.org/10.1038/s41408-021-00536-x Cite