Nicotinamide Inhibits Melanoma In Vitro and In Vivo

The anti-melanoma activity of Nicotinamide, the amide form of Niacin, was assessed in vitro and in vivo.
[Journal of Experimental & Clinical Cancer Research]
Scatozza, F., Moschella, F., D’Arcangelo, D., Rossi, S., Tabolacci, C., Giampietri, C., Proietti, E., Facchiano, F., & Facchiano, A. (2020). Nicotinamide inhibits melanoma in vitro and in vivo. Journal of Experimental & Clinical Cancer Research, 39(1), 211. https://doi.org/10.1186/s13046-020-01719-3 Cite
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Silencing p53 Inhibits Interleukin 10-Induced Activated Hepatic Stellate Cell Senescence and Fibrotic Degradation In Vivo

Scientists explored whether p53 played a crucial role in the senescence of activated hepatic stellate cells and degradation of collagen mediated by interleukin-10.
[Experimental Biology and Medicine]
Guo, Q., Chen, M., Chen, Q., Xiao, G., Chen, Z., Wang, X., & Huang, Y. (2020). Silencing p53 inhibits interleukin 10-induced activated hepatic stellate cell senescence and fibrotic degradation in vivo: Experimental Biology and Medicine. https://doi.org/10.1177/1535370220960391 Cite
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Decrease of T-Cells Exhaustion Markers Programmed Cell Death-1 and T-Cell Immunoglobulin and Mucin Domain-Containing Protein 3 and Plasma IL-10 Levels after Successful Treatment of Chronic Hepatitis C

Researchers studied 76 DAA-treated hepatitis C virus (HCV)-positive patients and 18 non-infected controls. Flow cytometry measured pretreatment frequencies of CD4+PD-1+, CD4+PD-1+Tim-3+ and CD8+PD-1+Tim-3+ T-cells and IL-10 levels measured by ELISA were significantly higher and CD4+PD-1Tim-3 and CD8+PD-1−Tim-3 T-cells were significantly lower in patients than in controls.
[Scientific Reports]
Decrease of T-cells exhaustion markers programmed cell death-1 and T-cell immunoglobulin and mucin domain-containing protein 3 and plasma IL-10 levels after successful treatment of chronic hepatitis C | Scientific Reports. (n.d.). Retrieved September 30, 2020, from https://www.nature.com/articles/s41598-020-73137-6 Cite
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Engineered IL-10 Variants Elicit Potent Immunomodulatory Effects at Low Ligand Doses

The authors explored whether the stability of the IL-10 receptor complex contributed to the immunomodulatory potency of IL-10.
[Science Signaling]
Gorby, C., Bellón, J. S., Wilmes, S., Warda, W., Pohler, E., Fyfe, P. K., Cozzani, A., Ferrand, C., Walter, M. R., Mitra, S., Piehler, J., & Moraga, I. (2020). Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses. Science Signaling, 13(649). https://doi.org/10.1126/scisignal.abc0653 Cite
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Applied Molecular Transport Announces First Patient Dosed in Phase II Study of Oral AMT-101 in Ulcerative Colitis

Applied Molecular Transport announced that the first patient has been dosed in a randomized, placebo-controlled, double-blind, multicenter Phase IIa study evaluating the efficacy and safety of oral AMT-101 in patients with moderate to severely active ulcerative colitis.
[Applied Molecular Transport]
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Applied Molecular Transport Announces First Patient Dosed in Phase II Study of Oral AMT-101 in Ulcerative Colitis

Applied Molecular Transport announced that the first patient has been dosed in a randomized, placebo-controlled, double-blind, multicenter Phase IIa study evaluating the efficacy and safety of oral AMT-101 in patients with moderate to severely active ulcerative colitis.
[Applied Molecular Transport ]
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Adoptive Transfer of Bone Marrow-Derived Dendritic Cells (BMDCs) Alleviates OVA-Induced Allergic Airway Inflammation in Asthmatic Mice

Scientists compared the effects of adoptively transferred SOCS3−/− and SOCS3+/+ bone marrow-derived dendritic cells on airway inflammation in ovalbumin-sensitized asthmatic mice.
[Scientific Reports]
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A Dynamic COVID-19 Immune Signature Includes Associations with Poor Prognosis

Investigators identified a core peripheral blood immune signature across 63 hospital-treated patients with COVID-19 who were otherwise highly heterogeneous.
[Nature Medicine]
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Extracellular Vesicle–Encapsulated IL-10 as Novel Nanotherapeutics against Ischemic AKI

Treatment with IL-10+ extracellular vesicles significantly ameliorated renal tubular injury and inflammation caused by ischemia/reperfusion injury, and potently prevented the transition to chronic kidney disease.
[Science Advances]
Tang, T.-T., Wang, B., Wu, M., Li, Z.-L., Feng, Y., Cao, J.-Y., Yin, D., Liu, H., Tang, R.-N., Crowley, S. D., Lv, L.-L., & Liu, B.-C. (2020). Extracellular vesicle–encapsulated IL-10 as novel nanotherapeutics against ischemic AKI. Science Advances, 6(33), eaaz0748. https://doi.org/10.1126/sciadv.aaz0748 Cite
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Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-Inflammatory Effects Through SHIP1/STAT3 Complexes

Scientists report that IL10, but not IL6 signaling, induced formation of a complex between STAT3 and the inositol polyphosphate-5-phosphatase SHIP1 in macrophages.
[iScience]
Chamberlain, T. C., Cheung, S. T., Yoon, J. S. J., Ming-Lum, A., Gardill, B. R., Shakibakho, S., Dzananovic, E., Ban, F., Samiea, A., Jawanda, K., Priatel, J., Krystal, G., Ong, C. J., Cherkasov, A., Andersen, R. J., McKenna, S. A., Petegem, F. V., & Mui, A. L.-F. (2020). Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-Inflammatory Effects Through SHIP1/STAT3 Complexes. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101433 Cite
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Comparative Study between Human Mesenchymal Stem Cells and Etanercept as Immunomodulatory Agents in Rat Model of Rheumatoid Arthritis

Adipose tissue mesenchymal stem cells were able to delay the onset of collagen-induced arthritis, suppress the ongoing clinical and histopathological signs, decrease serum levels of TNF-α and anti-collagen type II, and downregulate the autoreactive T cells as etanercept.
[Immunologic Research]
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