Discrimination of Hand-Foot Skin Reaction Caused by Tyrosine Kinase Inhibitors Based on Direct Keratinocyte Toxicity and Vascular Endothelial Growth Factor Receptor-2 Inhibition

The authors explained the incidence of hand-foot skin reaction in patients treated with tyrosine kinase inhibitors by focusing on keratinocyte toxicity and inhibition of vascular endothelial growth factor receptor, which played an essential role in angiogenesis.