hematopoietic stem cells

[Cell Research] Scientists constructed a spatiotemporal transcriptome map of mouse fetal liver as a platform for experimental validation of novel regulatory mechanisms underlying HSC and multipotent progenitor expansion.

[Cell Stem Cell] Researchers showed that lysosomes were regulated dichotomously by transcription factor EB (TFEB) and MYC to balance catabolic and anabolic processes required for activating long-term-HSCs and guiding their lineage fate.

[Journal of Cellular and Molecular Medicine] Investigators showed that endogenous stimuli and VEGF were sufficient to induce robust human pluripotent stem cell-derived hematopoiesis, intensive generation of hematopoietic progenitors, maturation of blood cells and the emergence of definitive precursor cells including those that were phenotypically identical to early human embryonic HSCs.

[Journal of Immunology] Investigators reported that TLR4 was expressed on granulo-monocytic progenitors, as well as mobilized human peripheral blood CD34+ cells. LPS, a component of Gram-negative bacteria that results in a systemic bacterial infection, induced the differentiation of peripheral blood CD34+ cells into myelocytes and monocytes in vitro via the TLR4 signaling pathway.

[Cell Research] Single-cell transcriptomics revealed three transcriptionally heterogeneous hematopoietic stem cell and multipotent progenitor subsets, among which a CD93-enriched subset exhibited enhanced stem cell properties.

[Blood] Researchers used long-term quantitative single-cell imaging to show that lysosomes and active mitochondria were asymmetrically inherited in human blood stem cells and that their inheritance was a coordinated, non-random process.