hepatic cells

[NPJ Regenerative Medicine] The authors suggested that mesenchymal stromal cells ameliorated surgery-induced hepatocellular stress and epithelial-mesenchymal transition, thus supporting epithelial integrity and facilitating regeneration.

[Parasites & Vectors] Researchers investigated the role of Echinococcus multilocularis protoscoleces (PSCs) in hepatic fibrosis by examining structural changes and measuring hepatic fibrosis-related protein levels in cocultures of PSCs and human hepatic stellate cells.

[Cell Death & Differentiation] Researchers demonstrated a crucial role of Bcl-3, an IκB family member, in regulating tumor necrosis factor-α (TNF)-induced hepatic cell death.

[Signal Transduction and Targeted Therapy] Fragmented mitochondria fueled actin filament remodeling and lamellipodia or invadopodia formation to facilitate cell metastasis in hepatocellular carcinoma cells both in vitro and in vivo.

[Signal Transduction and Targeted Therapy] The authors showed that natural killer (NK)-derived exosomes from lean mice attenuated obesity-induced insulin resistance and inflammation in mice of type 2 diabetes, and that lean NK-derived exosomes enhanced insulin sensitivity and relieve inflammation in adipocytes and hepatocytes.

[Journal of Controlled Release] Investigators developed a specific aptamer against EpCAM and tested its potential as a drug delivery agent for hepatocellular carcinoma.