in silico

[Scientific Reports] Computational analysis using Ingenuity Pathway Analysis identified multiple activated signaling networks in colorectal cancer (CRC), including ERBB2, RABL6, FOXM1, and NFKB networks, while functional annotation highlighted activation of cell proliferation and migration as the hallmark of CRC.

[American Journal of Physiology-Gastrointestinal and Liver Physiology] Investigators demonstrated a novel finding in which miR-29a, b and c down-regulated SMCT-1 expression in colonic epithelial cells and may have partly explained the differential expression of these transporters along the length of the gastrointestinal tract.

[Cell Death & Disease] Researchers investigated the involvement of zinc finger protein 36 (ZFP36) and cAMP‐response element-binding protein binding protein (CREBBP) on ischemia–reperfusion (I/R)-induced lung injury in vivo and in vitro.

[Scientific Reports] An in-silico approach has been adopted to construct a multi-epitope vaccine from selected immunogenic extracellular vesicle proteins to elicit a cellular as well as a humoral immune response.

[npj Biofilms and Microbiomes] Investigators highlighted key steps in the aryl polyene biosynthesis pathway that could be explored as potential drug targets for complementary strategies to reduce fitness and prevent biofilm formation of multi-drug resistant pathogens.

[Journal of Biomolecular Structure and Dynamics] Scientists investigated the impact of hydrophobic aromatic moieties in the peptide linker on prostate specific membrane antigen affinity and in vitro performance.