in silico

[Acta Neuropathologica Communications] Whether sensory neuronal activity is important for tumor progression remains unknown. Researchers suggested that sensory innervations regulate melanoma progression, indicating that manipulation of sensory neurons’ activity may provide a valuable tool to improve melanoma patients’ outcomes.

[GNS Healthcare] GNS Healthcare and Scipher Medicine announced plans to develop and launch Gemini— the in silico Patient™ for rheumatoid arthritis, to help patients reach target treatments sooner.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers found that, in contrast to current convention, “immunodominant” SARS-CoV-2 peptides defined by in silico methods often failed to elicit T cell responses recognizing naturally presented SARS-CoV-2 epitopes.

[Journal of Nuclear Medicine] Scientists reported that targeting β1 integrin (β1I) significantly improved radium 223 outcome and points towards combinatorial application in prostate cancer tumors with high β1I expression.

[Cell Death & Disease] The authors used a murine model of orthotopic breast cancer to study the tumor-intrinsic role of cyclin-dependent kinase 8 (CDK8) in TNBC and linked CDK8 to programmed death-ligand 1 expression.

[Scientific Reports] Researchers identified differentially expressed genes via a comparison between luminal A breast cancer subtypes and normal mammary ductal cells from healthy donors.