induced pluripotent stem cells

[Molecular Psychiatry] The authors discuss how deficits in neurodevelopmental processes may lead to abnormal brain connectivity and how iPSC-based models can be used to identify abnormal connections and to gain insights into underlying cellular and molecular mechanisms to develop novel therapeutics.

[Adaptimmune Therapeutics plc] Adaptimmune Therapeutics plc announced that it has entered into a strategic collaboration and license agreement with Genentech to develop and commercialize allogeneic cell therapies to treat multiple oncology indications. Adaptimmune will be responsible for developing clinical candidates using its iPSC derived allogeneic platform to produce T-cells.

[Stem Cell Research & Therapy] Investigators developed precise culture conditions for gastric organoids in vitro to improve the accuracy of the generation of organoid models for therapeutic and medical applications.

[Scientific Reports] The Hippo pathway regulates the proliferation of cancer cells, pluripotent stem cells, and epithelial cells through a cell–cell contact-dependent manner, however, it is unclear if cell density-dependent cell proliferation is a consistent feature in cardiac myocytes. Scientists used cultured human iPSC-derived cardiac myocytes as a model system to investigate this concept.

[Communications Biology] The authors described a two-step chemically defined xeno-free method for generating valvular endothelial cell (VEC)-like cells (VELs) from human PSCs (hPSC). When seeded onto the surface of the de-cellularized porcine aortic valve matrix scaffolds, hPSC-derived VELs exhibited superior proliferative and clonogenic potential than the primary VECs and human aortic endothelial cells.

[Cell Stem Cell] Investigators showed an in vitro reconstitution of whole male germ-cell development by PSCs. Mouse ESCs were induced into primordial germ cell-like cells, which were expanded for epigenetic reprogramming.