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induced pluripotent stem cells

Epigenetic Clocks Reveal a Rejuvenation Event during Embryogenesis Followed by Aging

[Science Advances] Researchers developed a multi-tissue epigenetic clock and applied it to track changes in biological age during mouse and human prenatal development. This analysis revealed a significant decrease in biological age during early stages of embryogenesis, followed by an increase in later stages.

SISTEMA: A Large and Standardized Collection of Transcriptome Datasets for Human Pluripotent Stem Cell Research

[iScience] The authors developed SISTEMA, a quality-controlled curated gene expression database, built on a valuable catalogue of human PSC lines and their derivatives for which a transcriptomic analysis was generated using a single experimental pipeline.

Continuous Monitoring Reveals Protective Effects of N-Acetylcysteine Amide on an Isogenic Microphysiological Model of the Neurovascular Unit

[Small] Investigators reported the first model of the blood-brain barrier featuring both isogenic human induced pluripotent stem cell-derived cells and continuous barrier integrity monitoring with under 2 min temporal resolution.

Immunological Considerations and Challenges for Regenerative Cellular Therapies

[Communications Biology] Scientists describe the role of the host innate and adaptive immune responses as triggers of allogeneic graft rejection. They discuss how the immune response is determined by the cellular therapy.

Efficient Generation of Dopaminergic Induced Neuronal Cells with Midbrain Characteristics

[Stem Cell Reports] Investigators explored the generation of dopaminergic induced neuronal cells from mouse and human PSCs, and found that the proneural factor Ascl1 in combination with mesencephalic factors Lmx1a and Nurr1 induced peripheral dopaminergic neurons.

Intestinal Organoids: Roadmap to the Clinic

[American Journal of Physiology-Gastrointestinal and Liver Physiology] The authors outline the critical areas and challenges that must be addressed when transitioning laboratory-based discovery of intestinal organoids, through an investigational new drug application to first-in-human clinical trial, and encourage investigators to consider the required regulatory steps from the earliest stage of the translational process.

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