insulin producing cells

[Cold Spring Harbor Perspectives in Biology] Scientists describe the development and function of β-cells the emerging concept of heterogeneity within insulin-producing cells, and the potential of other cell types to assume β-cell functionality via transdifferentiation.

[Stem Cell Reviews and Reports] For the purpose of easy monitoring of differentiation efficiencies into pancreatic progenitors and insulin-producing cells, scientists generated new reporter lines by knocking in a P2A-H-2Kk-F2A-GFP2 reporter gene into the SOX9-locus and a P2A-mCherry reporter gene into the INS-locus mediated by CRISPR/CAS9-technology.

[Stem Cells Translational Medicine] Scientists discuss the potential of both stem cell-derived pancreatic progenitors and more matured insulin-producing cells to treat diabetes.

[ACS Biomaterials Science & Engineering] Hydrogel prepared with alginate and the pancreatic extracellular matrix was assessed for the beneficial outcomes on encapsulated insulin-producing cells.

[Advanced Science] The design considerations and functional requirements of macroencapsulation systems are reviewed, specifically for stem-cell derived islets, highlighting distinct design parameters.

[Scientific Reports] Researchers investigated insulin-producing cell generation from two practical canine MSCs, canine bone marrow-derived MSC, and canine adipose-derived MSCs.