insulin

[Nature Communications] RNA-seq of purified recombined β-cells reveals transcriptomic consequences of Insr loss, which differ between female and male mice.

[Connective Tissue Research] The protein level of insulin-like growth factor 1 receptor (IGF-1 R), detected as the upstream molecule of Yes-associated protein (YAP), was reduced in the INS-1 cells cultured on the dishes coated with collagen V.

[Diabetes] Following beta cell ablation of Yy1, scientists observed rapid onset of hyperglycemia, impaired glucose tolerance and reduced beta cell mass in both neonates and adult mice.

[GeroScience] Researchers reanalyzed existing RNA-seq data, comparing the transcriptome in the aorta arch samples isolated from isochronic parabiont aged C57BL/6 mice.

[Proceedings of the National Academy of Sciences of the United States of America] In vitro knockdown of either cullin 1 or cullin 3, but not other cullin members, attenuated insulin-induced insulin receptor substrate protein degradation and enhanced cellular insulin signaling activation.

[Nature Medicine] Researchers generated islets from human chemically induced PSCs (hCiPSC-islets) and showed that a one-dose intraportal infusion of hCiPSC-islets into diabetic non-human primates effectively restored endogenous insulin secretion and improved glycemic control.