Cullin Neddylation Inhibitor Attenuates Hyperglycemia by Enhancing Hepatic Insulin Signaling through Insulin Receptor Substrate Stabilization

By
Justin.choi
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0
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In vitro knockdown of either cullin 1 or cullin 3, but not other cullin members, attenuated insulin-induced insulin receptor substrate protein degradation and enhanced cellular insulin signaling activation.
[Proceedings of the National Academy of Sciences of the United States of America]
Abstract