insulin

[Nature Reviews Neuroscience] The authors review evidence showing that brain inflammation and activation of cellular stress response mechanisms comprise molecular underpinnings of impaired brain insulin signaling in Alzheimer disease (AD) and integrate impaired insulin signaling with AD pathology.

[Nature Communications] Hepatocyte nicotinamide phosphoribosyltransferase conveyed key aspects of the fasting response, which selectively dissociated through hepatocyte SIRT1.

[Nature Communications] Targeting Mat1a activated the liver-brown adipose tissue axis by increasing NRF2-mediated FGF21 secretion, which prevented obesity, insulin resistance and hepatosteatosis.

[Nature Metabolism] Mechanistically, the protective role of microsomal prostaglandin E synthase-2 (mPGES-2) deletion was induced by antagonizing β-cell senescence via interference of the PGE2–EP3–NR4A1 signaling axis.

[Free Radical Biology and Medicine] Researchers investigated whether peri-pancreatic white adipose tissue produced oxygenated lipids, namely isoprostanes and neuroprostanes and whether they can influence β-cell function in obesity.

[Nature Metabolism] Scientists provided a single-cell atlas of pancreatic islets of 24 type 1 diabetes, autoantibody-positive and nondiabetic organ donors across multiple quantitative modalities including ~80,000 cells using single-cell transcriptomics, ~7,000,000 cells using cytometry by time of flight and ~1,000,000 cells using in situ imaging mass cytometry.