intestinal cells

[Biochemical Genetics] The authors studied the mechanism of miR-122 in regulating intestinal barrier function in acute pancreatitis (AP). AP rat model was constructed via intraperitoneal injection of ketamine, and primary intestinal epithelial cells were isolated from rats for in vitro studies.

[Nature Cell Biology] Prostaglandin E2 signaling via the E-type prostanoid receptor 4 (EP4) on intestinal epithelial cells repressed epithelial necroptosis and induced resolution of colitis. EP4 expression correlated with an improved IBD outcome and EP4 activation induced a transcriptional signature consistent with resolution of intestinal inflammation.

[Nature] Apc-mutant intestinal stem cell (ISCs) functioned as bona fide supercompetitors by secreting WNT antagonists, thereby inducing differentiation of neighbouring wild-type ISCs.

[Current Opinion in Cell Biology] The authors review recent findings on how adult intestinal stem cells differentiate, interact with their environment, and change during aging.

[Scientific Reports] Scientists demonstrated that membrane vesicles from Lacticaseibacillus rhamnosus JB-1 were endocytosed in a likely clathrin-dependent manner by both mouse and human intestinal epithelial cells (IECs) in vitro and by mouse IEC in vivo.

[Developmental Cell] Using a Drosophila intestinal model, scientists found that tumor cells outcompeted nearby enterocytes by influencing cell adhesion and contractility.