E-Type Prostanoid Receptor 4 Drives Resolution of Intestinal Inflammation by Blocking Epithelial Necroptosis

Prostaglandin E2 signaling via the E-type prostanoid receptor 4 (EP4) on intestinal epithelial cells repressed epithelial necroptosis and induced resolution of colitis. EP4 expression correlated with an improved IBD outcome and EP4 activation induced a transcriptional signature consistent with resolution of intestinal inflammation.